Rumored Buzz on indazole derivatives
Substitution at R3 which has a halogen or alkoxy group (74f–74i) triggered a slight boost in cellular potency With all the halide analogs (74g–h) displaying highest the potency within the group. Additional optimization led to the invention of 74i–j, with 74k as one of the most active compound within the collection (pIC50 = 6.seventy seven) wi